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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de20c7186af9b3747660e22fc8ad5a780811eae84dd4ed5d144d7d99d45d512c' 
  AND token = 'aDY8WDQxGesgyu2Ssr0s3329vxZ/TVA0fFVYhmQhBXo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}