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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4536030c51bf24122d9816b7028013c3e0a33981e1dcc9939eec03bb7d297c19' 
  AND token = 'hDQYiv6V1JAl8FXyPmKWHbOGMOdbYfcVPoOFpQjfIKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}