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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8549e6ad758fcf5db6f495e1f696a16d2003f9bf1c78788a7708be00c0a6de2e' 
  AND token = 'e/iDaBV24S+3rQsKXK5UCLo6aHKDCo8sYOBVgQrF9mo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}