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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e12bd34c8251a21fbe6fe3e0eede17f0bb9cfa7d7b41793fcaab82646b9d94b1' 
  AND token = 'F9xXe0soC496oGmUvLJCGkucLiTRSJkEIXSai4HMwdI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}