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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81d1d671a5e8ef4a2d4411a2e4fc8068dcb591b52764056a13b4a861af5ff041' 
  AND token = 'pIJd4UISVbGkH0mMn0YlJVgojeLibUVzjYQbPx84Ujc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}