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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0448ee67e558b50e50df31544999a91d835c904626fde73d1b10b19877addd65' 
  AND token = 'dRfHzdh25eaoP1U1pfEVTgNn6P8oMmayV73GDeC8UQw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}