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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c0472870ec5b818b133cda61b11f1d85f3a353c3dfab030f8a27de9b04b11f9' 
  AND token = 'u/2MZiuHeQRTiCWL47R/j9VzdLG7CkiEjL+0p/U0M2E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}