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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '527f7e20c2c934a94e67590ed13745d6e4f6478ce551a7d00e604c80c0153af5' 
  AND token = 'yY5SjXg/a1Y0UCk+fiLVoQPZq5qKoP9uWrxGQQ3ByNA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}