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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b8832e4f9c4853d6f42f396fa475090523705e6a8df8ca263e6a5ca147605a' 
  AND token = 'UT2QqBvGBSsIDyPGN5k53YzUNS0ZxaL7BKy6XiT2vvw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}