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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '448022aadcc03166aa1f8ec932cb4b4271b46d0f6f265881b6a2270fa8c6b9cb' 
  AND token = 'Xg3CEDuL3Vqdt9RzdqSXMRsbDLiKKziyY3X+/wSgDM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}