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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65d3b000040a41fbfd8fb17bab1160e5f908a8b44fe65e9f0dfe6128360920bc' 
  AND token = 'qCfD+bUmJZY//HMB3eOtEt5k2OYZkSiL4lAlgBXtQp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}