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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a78bb86d5585b9d57761630b20ebba69688986c0f586d40a573d35f9ea10b2' 
  AND token = '4wzBLSlprWHkYQxA/HV+to/xYLdxwHJy5050FWWvvco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}