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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a4b135ba8a9f0d80415a87f6c393c64c292e09a643b712f6f40e24eebd40d43' 
  AND token = 'OqL7YS/GO7NfMWvi8GDbaU+RRJR0SdnbFUOpAYL8JJs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}