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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2160598459ae857f1b92b6c1889fc80e0ad28195fd0d8ebcbe88325eb6889878' 
  AND token = 'Aen7YOOtFXS9Dei3/+2CsyRmp6AHA3rQnuQ0FiyHP50=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}