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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '644e97b57278486bb2120cde3561321df3029be27639086bef195768a331042e' 
  AND token = 'h+w/IVxtT3RAdveC9pfiW/DpAfW29Wge+QeagLeMEsM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}