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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f81052f775ebb07c40a3c6e5b6f977c0aa7449c5542ae3316048d54474f9b252' 
  AND token = 'xgN/XnE/yxpOOSPPNhPQl8A9FBCnz7k1vqdp3gkB6UA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}