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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4b14854a727e3b29200bb5535a660fe2eb391def8913140533e7c8770e697f1' 
  AND token = 'lD4fHO+c2xx1xMic3Y42/lHTV4iFqhGjMiilebZEfJw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}