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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ed3f4455fd367230b2bb2f4098556f09eda9b7bfd2eaaf0c079341f01a2227' 
  AND token = '1tB99Mgl1dn+uzJM/m6MhC+EZQqZf2fFMX5P1hUQLDo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}