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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '643700f645819c0e2b3c73b490acb30e5abd3d1f1db846ceda8d5bcf364a58a1' 
  AND token = 'I3yGbefpWliI5t00qXB+7edBjaYRX66rTO3x7Bo4KMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}