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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ea144e1851951f2799adf5d61e4c45cd736424f14ab3b505f5609727d6bc0d5' 
  AND token = 'JEzql8ipXN2SI/pcznLkhh31PsW2BApi98CWWW9BV+0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}