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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78a595d905e08de4406068cec2b9dd75f1f9c38bb45ad76e88ba0f48029c3329' 
  AND token = '5/2YDJ2nHvPuE+tmH6nnP42n6ZuVLNCCF9gch8aKDTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}