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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '133a449f04fdd845967e217d48af2dc256d0cb2eeac5b31b3c6f086a4b4f7f40' 
  AND token = 'U5vnbkQsAtTq3obEkgALJd2qynBtr9fxEOBamJWmWgI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}