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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5ea253eb5169f38d1f52afd38986d60b91dd3ff121bfdc09b1b640bf0159221' 
  AND token = 'X3Z8UEJY+fsmF4uisWp4zwkCmJmxXVyFlIbNb/uw1gI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}