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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42a3b500aa1d0cc0339826ede7f7ec376534e3a066ffe120425bac14369aa948' 
  AND token = '41/vJCqtUCsc2fcSHThUb3ZC2Wr8W+XHZ4XvvsXa0h4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}