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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f62b2a17b423474f45efcd4e1e11064992064773b2d77a847398c620e2cdf8' 
  AND token = 'PuoTQ2x+PZjW01jsjvowG7N8tiAhFutOl+w6fhtRmzQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}