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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b5fd430b1c0b10632a76a42ad60081e600e816d014cccd3f6f18d9b29b4e5f0' 
  AND token = 'd7Opq6SNTSTQvCtXgY3l++e/VGsFbXbgdCRnGWnpu0k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}