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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aac57b159099eb5bb4cbaf9caf1374f1650bc78e728f3cfaca1cc4ae284b1122' 
  AND token = 'lAgdJ2nMn1NzGZvmm+VM9J5xGd7WdOE8Cie2nFB8zQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}