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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6acac0b1a9c6b85961f3b08f94d3eaeee4ef39ad4a41e873ae065cf38f155b05' 
  AND token = 'JGOAbhKtce8Mbz1Ipsgx9cTXufZSPcOXg0kBn4sYUd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}