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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a18bf0c7f1780df216cc875e144dae451173f7b09f69188d6dcacd2c883daf22' 
  AND token = 'HOA4dDZ9sZjHnP76z7vXXvpeJJNMlHaL1mP2NY2rVgU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}