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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c00a197f41912c64944395e48aa5e1103711fdea70521b4d4e53883a380fbb0' 
  AND token = 'UuZcGVwbKkJ3X+k0n6AwROyrRs40uW1tCuO5TM2uh/E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}