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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fa80a51194f90bec3fa2144cc6bf6e4c90f08e89a3df3afa438876c99072979c' 
  AND token = 'anZu/B0NirdUyxlp/SMjoKmEY+So6KHo5QYaOGP8Gg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}