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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4488ed2df2e96fb9bd0b4d14c38c883a454b6bbac162b165fd67840e2931f857' 
  AND token = 'XMrbi967GBODHuusVx38tm85VwqywhjwUlsylprrUOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}