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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2722412ca3715911c4afe5e1ab1c5dfb2f2be8f2e0d2f0ccc2f997fca8770482' 
  AND token = '8MDaUJ0Q3AZemFJ/zSuVVSq4kPciMFPM+ummGKOCptI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}