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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75e4f32b46f1f5c9a1fb3b81247c3fff488dffc4faaafc102093faad41e1854c' 
  AND token = 'P2xYuoAkI5C5HFqTzhVH6wMIpKYk5cR5MeCAXlPCo+4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}