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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd7a3b1de84c737c5e0529bd817b120d42ad00d84a1a477c329a3e5a93ce3be05' 
  AND token = 'shuB7Kd1SmytrmHO3/kcIcuOcQHWEVLdSltQzofW1ng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}