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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd38caee874fd17f8fe09cd2fe5492002bc9b722ced38eccf203f815d8c295eb2' 
  AND token = '/sP+ulQeCPhu9Rh6HWXN9YtcTEIKktzeZ31bgzBTCDA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}