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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01b45488db8147eb3da76cede751cf7df2d64b2353b79e65199d4d521c05b721' 
  AND token = 'ODYRebuTM/3LXO1vBvvWrYsuY0N5tmSIE44HSNTBgyM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}