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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ad5c57696d50aebeb09dae40733f1527f21922c51786239b91e3adcd2e6f2f9' 
  AND token = 'CsqIXiOxz7sAyq77O+GDKt0s9/so7tHDM0znJKR9NIY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}