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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2282322b019911a5f8d4adc382c13e1b1f9b5e3f04f72303cb1e11448a4fad86' 
  AND token = 'RXfcz7GJriRqzjpk1Ks+kBtHxHDI9bZQKF4chbiu8Ig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}