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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ceaf20981392ac0d1490fb458ea9b47dec4d2652e1533610911267040e95fcb9' 
  AND token = 'FVW1Iqo/k4u7wN6VdD3DzGvVgLh6dre9bWvZiLzTtbM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}