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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e18a707b0a3eeda44bd2e10d304c71e76bc686cbb3eceb1c1a121024178d591' 
  AND token = 'UdAOXkbSn0mAHjCLmxT80SM+hjomP9ZtEdAgf0OdMcQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}