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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'afed4f7f818ba59bd4ff21281d4cfc96507b638f3f658109e91218b333779a0c' 
  AND token = 'vCSN/rnTaehNd1y9H0tDdVKiZoNyC4+N6a9BRx3Mji0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}