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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd28159a49a0a5e6708d0be78480453f3f4251a8d5da97355d9db203ad934f3ae' 
  AND token = 'UYQBMqDMSx1TW+HChRcPoP7BK5sBA0Ly0sO3ASp22d0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}