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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aaa721c3c74becf130c2f0d4426735428c2f3e9852a8e00248f3af7206e0e864' 
  AND token = 'BOBg4tGVORhmxjZDYiRMEOW3GBtRLYE3R0aXbi547vM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}