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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12d278af7de4bc0752b4976ca4bd0f383ca752c4a9000549a4e4575550ca3df9' 
  AND token = 'cuu+EwWnoV8jWXjLa6AbxB/slOQLcAaKgeZfb4mBhY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}