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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28defd1c300a5a29fcc761e3c6ddc9ca28015d8023278e80b3e24aba62b05169' 
  AND token = 'S4FJZi4cAG34bTJ/KiSI5VHD4J2+29LpdO/hI5qwL6s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}