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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d235219113ac254b3b67d9affeb9742972a2455a4a09b5b59f41fe3a561d3d3' 
  AND token = 'T+K77jRL1n6SBhnwWxf4GpYAZ7NNnOC3SHEw2xCn7UM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}