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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18a5bbd38e651236b24e7f79300011750d7f9a245906ddc98d957307bda53aa2' 
  AND token = 'DXcCrmjdXbluSihnv2jryN9H1n0r4jZDaDfHVo+lzW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}