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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d0d84dc296e575dba6301e3a3474cc9ef574e9cd9b06c9f23899fc3af1b221b' 
  AND token = 'NjEHOU0GYmYJI2qFYUU6cMOhGwlHU0kZB5kBMsBHlic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}