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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e6b3b973009173eb7b1bdd4451cf7edf308b28d0f4b86de43dcd3457279d3fe2' 
  AND token = 'H8NpBLpfTTd0ZVm+sZ3geOZvDkC0EptjLLyiox+VMNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}